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数据与复现
BI
bio-methylation-based-detection
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Analyzes cfDNA methylation patterns for cancer detection using cfMeDIP-seq or bisulfite sequencing with MethylDackel. Identifies cancer-specific methylation signatures and performs tissue-of-origin deconvolution. Use when using methylation biomarkers for early cancer detection or minimal residual disease.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-methylation-based-detection
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- CLI：MethylDackel extract ，用于 methylation calling ，面向 cfDNA bisulfite data。
- 检测 cancer ，面向 cfDNA methylation patterns" → Analyze cell-free DNA methylation ，用于 multi-cancer early detection 、 tissue-of-origin 分类 ，使用 bisulfite 或 enzymatic conversion. CLI：MethylDackel extract ，用于 methylation calling ，面向 cfDNA bisulfite data。
- 分析 cfDNA methylation ，用于 cancer detection 、 tissue-of-origin analysis。
- MethylDackel extract \ reference.fa \ sample_bismark.bam \ --CHG \ --CHH \ -o sample_methylation。
原始文档
SKILL.md 摘录
Methods Overview
| Method | Description | cfDNA Input |
|---|---|---|
| cfMeDIP-seq | Enrichment-based, good for low input | >= 5 ng |
| Bisulfite-seq | Single-base resolution | >= 10 ng |
| EM-seq | Enzymatic, less degradation | >= 10 ng |
MethylDackel Pipeline
MethylDackel is actively maintained and integrated with nf-core/methylseq.
## Merge C and G strand calls
MethylDackel mergeContext \
reference.fa \
sample_methylation
适用场景
- 适合在使用 methylation biomarkers ，用于 early cancer detection 或 minimal residual disease时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- cfdna-preprocessing - Preprocess before methylation analysis
- fragment-analysis - Complement with fragmentomics
- methylation-analysis/bismark-alignment - General methylation processing
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