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bio-population-genetics-plink-basics

维护者 FreedomIntelligence · 最近更新 2026年4月1日

PLINK2 for GWAS QC, LD pruning, and basic population genetics.

OpenClawNanoClaw分析处理复现实验bio-population-genetics-plink-basics🧠 bioos extended suitebioos extended bioinformatics suiteplink2

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-population-genetics-plink-basics

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • File formats，conversion，、 quality control filtering ，支持 PLINK 1.9 、 2.0。
  • plink --vcf input.vcf.gz --make-bed --out output。

原始文档

SKILL.md 摘录

Binary Format (Recommended)

FileContents
.bedBinary genotype data
.bimVariant information (chr, ID, cM, pos, A1, A2)
.famSample information (FID, IID, father, mother, sex, pheno)

PLINK 2.0 Format

FileContents
.pgenBinary genotype data (compressed)
.pvarVariant information
.psamSample information

Text Format (Legacy)

FileContents
.pedGenotypes (FID, IID, father, mother, sex, pheno, genotypes)
.mapVariant positions (chr, ID, cM, pos)

适用场景

  • Use bio-population-genetics-plink-basics ，用于 genomics 、 bioinformatics workflows。
  • Apply bio-population-genetics-plink-basics to sequencing，variant，或 omics analysis tasks。

不适用场景

  • Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

上游相关技能

  • association-testing - GWAS with filtered data
  • population-structure - PCA after QC
  • variant-calling/vcf-basics - VCF format before conversion

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