数据与复现生物信息与基因组学FreedomIntelligence/OpenClaw-Medical-Skills数据与复现
BI

bio-rna-quantification-count-matrix-qc

维护者 FreedomIntelligence · 最近更新 2026年4月1日

QC count matrices: library size, zero inflation, gene detection rates.

OpenClawNanoClaw分析处理复现实验bio-rna-quantification-count-matrix-qc🧠 bioos extended suitebioos extended bioinformatics suiteqc

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-rna-quantification-count-matrix-qc

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • Quality control 、 exploratory analysis of count matrices before differential expression。
  • dds <- DESeq数据集FromTximport(txi,colData = coldata,design = ~ condition)。

原始文档

SKILL.md 摘录

From count matrix

counts <- read.csv('count_matrix.csv', row.names = 1) coldata <- data.frame(condition = factor(c('ctrl', 'ctrl', 'treat', 'treat')), row.names = colnames(counts)) dds <- DESeqDataSetFromMatrix(countData = counts, colData = coldata, design = ~ condition)


## Genes detected per sample

colSums(counts(dds) > 0)

## Counts summary

summary(colSums(counts(dds)))

适用场景

  • Use bio-rna-quantification-count-matrix-qc ,用于 genomics 、 bioinformatics workflows。
  • Apply bio-rna-quantification-count-matrix-qc to sequencing,variant,或 omics analysis tasks。

不适用场景

  • Do not rely on this catalog entry alone ,用于 installation 或 maintenance details。

上游相关技能

  • rna-quantification/featurecounts-counting - Generate counts
  • rna-quantification/tximport-workflow - Import transcript counts
  • differential-expression/de-visualization - Downstream visualization
  • differential-expression/deseq2-basics - DE analysis

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