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bio-tcr-bcr-analysis-vdjtools-analysis
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Calculate immune repertoire diversity metrics, compare samples, and track clonal dynamics using VDJtools. Use when analyzing repertoire diversity, finding shared clonotypes, or comparing immune profiles between conditions.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-tcr-bcr-analysis-vdjtools-analysis
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- CLI：vdjtools CalcDiversityStats，vdjtools OverlapPair，vdjtools PlotFancySpectratype。
- Compute diversity 、 overlap ，用于 my TCR repertoires" → Calculate repertoire diversity metrics，sample overlap，、 perform statistical comparisons between immune repertoire samples. CLI：vdjtools CalcDiversityStats，vdjtools OverlapPair，vdjtools PlotFancySpectratype。
- java -jar vdjtools.jar <command> [options]。
原始文档
SKILL.md 摘录
Basic Usage
Goal: Run VDJtools commands for immune repertoire analysis.
Approach: Invoke VDJtools via Java JAR or wrapper script with appropriate subcommand and options.
## Or with wrapper script
vdjtools <command> [options]
Calculate Diversity Metrics
Goal: Compute repertoire diversity indices (Shannon, Simpson, Chao1, Gini) across samples.
Approach: Run CalcDiversityStats with a metadata file linking sample files to sample IDs and conditions.
适用场景
- 适合在analyzing repertoire diversity，finding shared clonotypes，或 comparing immune profiles between conditions时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- mixcr-analysis - Generate input clonotype tables
- repertoire-visualization - Visualize VDJtools output
- immcantation-analysis - BCR-specific phylogenetics
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