数据与复现临床医学与医药FreedomIntelligence/OpenClaw-Medical-Skills数据与复现

bio-vcf-basics

维护者 FreedomIntelligence · 最近更新 2026年4月1日

View, query, and understand VCF/BCF variant files using bcftools and cyvcf2. Use when inspecting variants, extracting specific fields, or understanding VCF format structure.

OpenClawNanoClaw分析处理复现实验bio-vcf-basics🧬 bioinformatics (gptomics bio-* suite)bioinformatics — clinical databases & variant analysisview

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-vcf-basics

维护者: FreedomIntelligence
许可: MIT
最近更新: 2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

View 、 query variant files ，使用 bcftools 、 cyvcf2。
bcftools index -t input.vcf.gz。

原始文档

SKILL.md 摘录

Format Overview

Format	Description	Use Case
VCF	Text format, human-readable	Debugging, small files
VCF.gz	Compressed VCF (bgzip)	Standard distribution
BCF	Binary VCF	Fast processing, large files

Header Lines (##)

##fileformat - VCF version
##INFO - INFO field definitions
##FORMAT - FORMAT field definitions
##FILTER - Filter definitions
##contig - Reference contigs
##reference - Reference genome

Column Header (#CHROM)

Fixed columns: CHROM, POS, ID, REF, ALT, QUAL, FILTER, INFO, FORMAT Followed by sample columns

适用场景

适合在inspecting variants，extracting specific fields，或 understanding VCF format structure时使用。

不适用场景

Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

上游相关技能

variant-calling - Generate VCF from alignments
filtering-best-practices - Filter variants by quality/criteria
vcf-manipulation - Merge, concat, intersect VCFs
alignment-files/pileup-generation - Generate pileup for calling

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