数据与复现统计与数据分析FreedomIntelligence/OpenClaw-Medical-Skills数据与复现

bio-vcf-statistics

维护者 FreedomIntelligence · 最近更新 2026年4月1日

bio-vcf-statistics：生成 variant statistics，sample concordance，、 quality metrics ，使用 bcftools stats 、 gtcheck。适合在evaluating variant quality，comparing samples，或 summarizing VCF contents时使用。

OpenClawNanoClaw分析处理复现实验bio-vcf-statistics🧬 bioinformatics (gptomics bio-* suite)bioinformatics — clinical databases & variant analysisgenerate

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-vcf-statistics

维护者: FreedomIntelligence
许可: MIT
最近更新: 2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

生成 statistics 、 quality metrics ，使用 bcftools。
bcftools view -v snps -H input.vcf.gz | wc -l。

原始文档

SKILL.md 摘录

Statistics Tools

Command	Purpose
`bcftools stats`	Comprehensive variant statistics
`bcftools gtcheck`	Sample concordance and relatedness
`bcftools query`	Custom summaries

bcftools stats

Goal: Generate comprehensive variant statistics including counts, Ti/Tv ratio, and quality distributions.

Approach: Run bcftools stats and parse section-tagged output lines (SN, TSTV, AF, QUAL, DP).

"How many variants are in this VCF?" → Compute summary counts, substitution types, and quality distributions from variant records.

View Key Metrics

Output sections:

SN - Summary numbers
TSTV - Transitions/transversions
SiS - Singleton stats
AF - Allele frequency distribution
QUAL - Quality distribution
IDD - Indel distribution
ST - Substitution types
DP - Depth distribution

适用场景

适合在evaluating variant quality，comparing samples，或 summarizing VCF contents时使用。

不适用场景

Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

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