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数据与复现
BI
bio-workflows-gwas-pipeline
维护者 FreedomIntelligence · 最近更新 2026年4月1日
GWAS: QC → imputation → association → fine-mapping → annotation.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/bio-workflows-gwas-pipeline
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Complete workflow ，用于 genome-wide association studies ，面向 genotype data to significant associations。
- plink2 --vcf input.vcf.gz \ --make-bed \ --out study。
原始文档
SKILL.md 摘录
Or with phenotype/covariate files
plink2 --vcf input.vcf.gz
--pheno phenotypes.txt
--make-bed
--out study
## Calculate sample statistics
plink2 --bfile study \
--missing \
--out study_stats
## Remove samples with high missing rate (>5%)
plink2 --bfile study \
--mind 0.05 \
--make-bed \
--out study_sample_qc
适用场景
- Use bio-workflows-gwas-pipeline ，用于 genomics 、 bioinformatics workflows。
- Apply bio-workflows-gwas-pipeline to sequencing，variant，或 omics analysis tasks。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- population-genetics/plink-basics - PLINK file formats and commands
- population-genetics/population-structure - PCA and admixture
- population-genetics/association-testing - Statistical models
- population-genetics/linkage-disequilibrium - LD concepts
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