数据与复现临床医学与医药FreedomIntelligence/OpenClaw-Medical-Skills数据与复现

chip-clonal-hematopoiesis-agent

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Clonal hematopoiesis of indeterminate potential (CHIP) variant detection and risk assessment.

OpenClawNanoClaw分析处理复现实验chip-clonal-hematopoiesis-agent🧠 bioos extended suitehematology & blood disordersclonal

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/chip-clonal-hematopoiesis-agent

技能摘要

2 min

CHIP Clonal Hematopoiesis Agent provides comprehensive detection 、 risk stratification of clonal hematopoiesis of indeterminate potential (CHIP). It identifies clonal mutations in blood cells，assesses risk of progression to myeloid malignancy，、 predicts cardiovascular disease risk，integrating ，支持 CHIC 机器学习框架，用于 CBC-based screening。
When detecting CHIP mutations ，面向 blood sequencing data。
用于 stratifying risk of progression to MDS/AML。
To assess CHIP-associated cardiovascular disease risk。
When filtering CHIP variants ，面向 tumor liquid biopsy。

原始文档

Gene	Frequency	Malignancy Risk	CVD Risk
DNMT3A	50%	Moderate	Elevated
TET2	20%	Moderate	Elevated (inflammatory)
ASXL1	10%	High	Moderate
JAK2	5%	High (MPN)	Elevated (thrombosis)
TP53	5%	Very High	Low
SF3B1	3%	Moderate-High	Low
SRSF2	3%	High	Low
PPM1D	2%	Moderate	Therapy-related
CBL	2%	High	Moderate
IDH1/2	2%	Moderate-High	Low

Category	Criteria	Annual AML Risk
Low-Risk CHIP	DNMT3A/TET2, VAF <10%	<0.5%
Intermediate CHIP	DNMT3A/TET2, VAF >10%	0.5-1%
High-Risk CHIP	ASXL1, TP53, splicing	1-3%
CCUS	CHIP + cytopenia	3-10%
Pre-MDS	High-risk mutations + dysplasia	>10%