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chromosomal-instability-agent

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Quantify chromosomal instability (CIN) from copy number and SV data.

OpenClawNanoClaw分析处理复现实验chromosomal-instability-agent🧠 bioos extended suiteoncology & precision medicine agentsquantify

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/chromosomal-instability-agent

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • Chromosomal Instability Agent analyzes CIN signatures to predict cancer prognosis，immunotherapy response，、 therapeutic vulnerabilities. It integrates copy number alterations，aneuploidy scores，、 CIN-related gene expression ，用于 comprehensive genomic instability assessment。
  • When assessing tumor aneuploidy 、 chromosomal instability levels。
  • To predict prognosis based on CIN signatures。
  • 用于 identifying tumors vulnerable to CIN-targeted therapies (PARP，ATR，WEE1)。
  • When analyzing immune evasion mechanisms related to CIN。

原始文档

SKILL.md 摘录

Core Capabilities

  1. CIN Scoring: Calculate comprehensive CIN scores from copy number data.

  2. Aneuploidy Quantification: Measure arm-level and focal copy number alterations.

  3. CIN Gene Expression: Analyze CIN70 and other transcriptional signatures.

  4. Immune Correlation: Assess CIN-immune microenvironment relationships.

  5. Therapeutic Vulnerability: Identify CIN-targeted treatment options.

  6. Prognostic Modeling: Predict outcomes based on CIN signatures.

CIN Metrics

MetricCalculationInterpretation
Aneuploidy scoreArm-level alterationsChromosome-level CIN
SCNA burdenTotal CNV alterationsOverall instability
Weighted GIIFraction altered genomeFocal vs broad changes
CIN7070-gene signatureTranscriptional CIN
WGIIWeighted genome instabilityComprehensive score

CIN70 Signature Genes

Core genes reflecting CIN phenotype:

  • Mitotic checkpoint: BUB1, BUBR1, MAD2L1
  • Kinetochore: CENPA, CENPF, NDC80
  • DNA replication: MCM2-7, ORC1
  • Cell cycle: CCNB1, CCNB2, CDK1, PLK1
  • Chromosome segregation: AURKB, KIF2C, KIF11

适用场景

  • When assessing tumor aneuploidy 、 chromosomal instability levels。
  • To predict prognosis based on CIN signatures。
  • 用于 identifying tumors vulnerable to CIN-targeted therapies (PARP，ATR，WEE1)。

不适用场景

  • Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

上游相关技能

  • HRD_Analysis_Agent - For HR-specific instability
  • Pan_Cancer_MultiOmics_Agent - For pan-cancer context
  • Tumor_Clonal_Evolution_Agent - For evolutionary dynamics

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