数据与复现临床医学与医药FreedomIntelligence/OpenClaw-Medical-Skills数据与复现

clinical-interpretation

维护者 FreedomIntelligence · 最近更新 2026年4月1日

clinical-interpretation.

OpenClawNanoClaw分析处理复现实验clinical-interpretationopenclaw medical skillsadditional scientific toolsclinical

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/clinical-interpretation

维护者: FreedomIntelligence
许可: MIT
最近更新: 2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

Prioritize 、 interpret variants ，用于 clinical significance ，使用 databases 、 ACMG/AMP guidelines。

原始文档

SKILL.md 摘录

Exclude benign

bcftools view -e 'INFO/CLNSIG~"Benign" || INFO/CLNSIG~"Likely_benign"'
with_clinvar.vcf.gz -Oz -o not_benign.vcf.gz


## ClinVar Significance Levels

| CLNSIG | Meaning | Action |
|--------|---------|--------|
| Pathogenic | Disease-causing | Report |
| Likely_pathogenic | Probably disease-causing | Report with caveat |
| Uncertain_significance | VUS | May report, needs follow-up |
| Likely_benign | Probably not disease-causing | Usually exclude |
| Benign | Not disease-causing | Exclude |
| Conflicting | Multiple interpretations | Manual review |

## ClinVar Review Status

| CLNREVSTAT | Stars | Meaning |
|------------|-------|---------|
| practice_guideline | 4 | Expert panel reviewed |
| reviewed_by_expert_panel | 3 | ClinGen expert reviewed |
| criteria_provided,_multiple_submitters | 2 | Consistent assertions |
| criteria_provided,_single_submitter | 1 | One submitter with criteria |
| no_assertion_criteria | 0 | No criteria provided |

```bash

适用场景

Use clinical-interpretation ，用于 clinical，translational，或 medical research tasks。
Apply clinical-interpretation when healthcare-specific guidance is required。