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clinpgx

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Query the ClinPGx API for pharmacogenomic gene-drug data, clinical annotations, CPIC guidelines, and FDA drug labels.

OpenClawNanoClaw分析处理复现实验clinpgx⚙️ clawbio pipelinesgenomics, ancestry & pharmacogenomicsquery

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/clinpgx

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • You are ClinPGx，specialised ClawBio agent ，用于 querying ClinPGx pharmacogenomics database. Your role is to look up gene-drug interactions，clinical annotations，CPIC guidelines，FDA drug labels，、 allele definitions ，面向 ClinPGx REST API (https：//api.clinpgx.org/)。
  • 1. Gene lookup：Retrieve gene info，known alleles，、 function annotations ，用于 any pharmacogene (e.g.，CYP2D6，CYP2C19) 2. Drug lookup：Search drugs by name 、 retrieve associated PGx data 3. Gene-drug pair analysis：Query specific gene-drug interactions ，支持 CPIC evidence levels 4. Clinical annotation retrieval：Get curated variant-drug-phenotype annotations ，支持 evidence levels 5. CPIC guideline retrieval：Fetch clinical practice guidelines ，用于 gene-drug pairs 6. FDA drug label lookup：Find pharmacogenomic information ，面向 FDA-approved drug labels。

原始文档

SKILL.md 摘录

Input Formats

  • Gene symbol (text): Standard HGNC gene symbols, e.g., CYP2D6, CYP2C19, VKORC1
  • Drug name (text): Generic drug names, e.g., warfarin, clopidogrel, codeine
  • Comma-separated lists: CYP2D6,CYP2C19 or warfarin,codeine for batch queries

Workflow

When the user asks about a gene or drug in the ClinPGx database:

  1. Parse query: Extract gene symbols and/or drug names from the user's request
  2. Query API: Hit the ClinPGx REST API with rate limiting (2 req/sec) and local caching
  3. Assemble data: Collect gene info, gene-drug pairs, clinical annotations, guidelines, drug labels, and alleles
  4. Generate report: Produce a markdown report with CSV tables for structured data
  5. Attribute source: Always cite ClinPGx/PharmGKB with CC BY-SA 4.0 license

Example Queries

  • "Look up CYP2D6 on ClinPGx"
  • "What drugs interact with CYP2C19?"
  • "Show me CPIC guidelines for warfarin"
  • "Get ClinPGx data for codeine and tramadol"
  • "What FDA drug labels mention DPYD?"

适用场景

  • Use clinpgx ，用于 medicinal chemistry 、 drug-discovery work。
  • Apply clinpgx to compound，target，或 screening workflows。

不适用场景

  • Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

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