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数据与复现药物发现与化学信息学FreedomIntelligence/OpenClaw-Medical-Skills数据与复现
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crispr-offtarget-predictor

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Predict CRISPR Cas9/Cas12 off-target sites genome-wide with CRISPOR/Cas-OFFinder.

OpenClawNanoClaw分析处理复现实验crispr-offtarget-predictor🧠 bioos extended suitedrug discovery & designpredict

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/crispr-offtarget-predictor

维护者
FreedomIntelligence
许可
MIT
最近更新
2026年4月1日

技能摘要

来自 SKILL.md 的关键信息

2 min

核心说明

  • This skill identifies potential off-target binding sites ，用于 specific sgRNA sequence. It helps researchers assess specificity of their CRISPR design。
  • Designing new CRISPR experiments。
  • Validating sgRNA specificity before synthesis。
  • Analyzing potential safety risks in gene editing protocols。
  • Designing new CRISPR experiments. Validating sgRNA specificity before synthesis. * Analyzing potential safety risks in gene editing protocols。

原始文档

SKILL.md 摘录

Core Capabilities

  1. Mismatch Scoring: Calculates mismatch penalties for potential sites.
  2. PAM Validation: Filters targets based on PAM (Protospacer Adjacent Motif) compatibility.
  3. Risk Assessment: Categorizes off-targets as Low, Medium, or High risk.

Workflow

  1. Input: sgRNA sequence (20nt) and PAM (e.g., NGG).
  2. Analysis: Scans a reference library (mocked for this version) for similar sequences.
  3. Output: List of potential off-targets with locations and risk scores.

Example Usage

User: "Check sgRNA 'GAGTCCGAGCAGAAGAAGAA' for off-targets."

Agent Action:

适用场景

  • Designing new CRISPR experiments。
  • Validating sgRNA specificity before synthesis。

不适用场景

  • Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。

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