数据与复现临床医学与医药FreedomIntelligence/OpenClaw-Medical-Skills数据与复现

ctdna-dynamics-mrd-agent

维护者 FreedomIntelligence · 最近更新 2026年4月1日

Track ctDNA dynamics for minimal residual disease detection and treatment monitoring.

OpenClawNanoClaw分析处理复现实验ctdna-dynamics-mrd-agent🧠 bioos extended suiteoncology & precision medicine agentstrack

原始来源

FreedomIntelligence/OpenClaw-Medical-Skills

https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/ctdna-dynamics-mrd-agent

技能摘要

2 min

ctDNA Dynamics MRD Agent provides comprehensive analysis of circulating tumor DNA dynamics ，用于 molecular residual disease (MRD) detection，treatment response monitoring，、 early relapse prediction. It integrates tumor-informed 、 tumor-naive approaches ，支持 temporal modeling ，用于 longitudinal ctDNA analysis。
When monitoring minimal/molecular residual disease post-treatment。
用于 tracking treatment response through ctDNA kinetics。
To predict relapse before clinical/radiological detection。
When assessing tumor burden dynamics during therapy。

原始文档

MRD Detection: Ultra-sensitive detection of residual disease (LOD 0.001% VAF).
Kinetic Modeling: Model ctDNA clearance and doubling time.
Response Prediction: Predict treatment response from early ctDNA dynamics.
Relapse Prediction: Identify molecular relapse months before imaging.
Resistance Monitoring: Track emergence of resistance mutations.
Multi-Timepoint Integration: Analyze longitudinal ctDNA trajectories.

Approach	Method	LOD	Best Use Case
Tumor-Informed	Track known mutations	0.001%	Post-surgical MRD
Tumor-Naive	Panel-based detection	0.1%	Screening, unknown primary
WGS-Based	Fragmentomics + mutations	0.01%	Comprehensive profiling
Methylation	cfDNA methylation	0.1%	Tissue of origin, early detection