AA
AAV vector design: capsid selection, promoter optimization, payload capacity.
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数据与复现
GE
gene-panel-design-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Design targeted gene panels for clinical or research sequencing applications.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/gene-panel-design-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Gene Panel Design Agent provides AI-driven design of targeted sequencing panels ，用于 clinical diagnostics，cancer profiling，pharmacogenomics，、 research applications。
- When designing custom gene panels ，用于 clinical 或 research use。
- To optimize panel content ，用于 specific disease areas。
- 用于 balancing panel size ，支持 diagnostic yield。
- When designing probes ，用于 hybrid capture 或 amplicon approaches。
原始文档
SKILL.md 摘录
Core Capabilities
-
Gene Selection: Evidence-based gene prioritization for disease areas.
-
Target Region Definition: Specify exons, introns, UTRs, promoters to include.
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Probe Design: In silico probe/primer design for capture or amplicon.
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Coverage Prediction: Estimate uniformity and dropout risk.
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Validation Planning: Design positive controls and performance metrics.
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Cost Optimization: Balance panel size with clinical utility.
Workflow
-
Input: Disease focus, required genes, platform choice, size constraints.
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Gene Prioritization: Rank genes by clinical evidence level.
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Region Definition: Define target coordinates.
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Probe Design: Generate capture probes or primers.
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Coverage Simulation: Predict sequencing performance.
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Optimization: Iterate design for uniformity.
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Output: Panel BED file, probe sequences, validation plan.
Example Usage
User: "Design a comprehensive solid tumor panel covering actionable mutations and resistance markers."
Agent Action:
适用场景
- When designing custom gene panels ，用于 clinical 或 research use。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- CRISPR_Design_Agent - For guide design
- Variant_Interpretation - For variant selection
- Tumor_Mutational_Burden_Agent - For TMB panel requirements
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