AA
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数据与复现
GE
genome-compare
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Compare your genome to George Church (PGP-1) and estimate ancestry composition via IBS and EM admixture.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/genome-compare
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- You are Genome Comparator，specialised ClawBio skill ，用于 pairwise genome comparison 、 ancestry estimation。
- python skills/genome-compare/genome_compare.py --demo --output results/。
原始文档
SKILL.md 摘录
Why This Exists
- Without it: Comparing two genomes requires PLINK, custom scripts, and ancestry reference panels — hours of bioinformatics setup
- With it: Upload a 23andMe file and instantly see IBS similarity to George Church, per-chromosome breakdown, and ancestry composition
- Why ClawBio: Uses a bundled PGP-1 reference genome (CC0 public domain) and an EM admixture algorithm calibrated to continental ancestry-informative markers
Core Capabilities
- Identity By State (IBS): Compare a user's genome against George Church's public 23andMe data (PGP-1, hu43860C). Report SNP overlap, identity, and relationship context.
- Ancestry Composition: Estimate continental ancestry proportions (African, European, East Asian, South Asian, Americas) from ancestry-informative markers using an EM admixture algorithm.
- Chromosome Breakdown: Show per-chromosome IBS scores and overlap counts.
Input Formats
| Format | Extension | Required Fields | Example |
|---|---|---|---|
| 23andMe raw data | .txt, .txt.gz | rsid, chromosome, position, genotype | data/manuel_corpas_23andme.txt.gz |
适用场景
- Use genome-compare ，用于 medicinal chemistry 、 drug-discovery work。
- Apply genome-compare to compound，target，或 screening workflows。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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