AD
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Adaptyv is a cloud laboratory platform that provides automated protein testing and validation services. Submit protein s…
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数据与复现
GL
glycoengineering
维护者 Kuan-lin Huang · 最近更新 2026年4月1日
Glycosylation is the most common and complex post-translational modification (PTM) of proteins, affecting over 50% of all human proteins. Glycans regulate protein folding, stability, immune recognition, receptor interactions, and pharmacokinetics of therapeutic proteins. Glycoengineering involves rational modification of glycosylation patterns for improved therapeutic efficacy, stability, or immune evasion. **Two ma….
原始来源
K-Dense-AI/claude-scientific-skills
https://github.com/K-Dense-AI/claude-scientific-skills/tree/main/scientific-skills/glycoengineering
- 维护者
- Kuan-lin Huang
- 许可
- Unknown
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- N-glycosylation：Attached to asparagine (N) in sequon N-X-[S/T] where X ≠ Proline；occurs in ER/Golgi。
- O-glycosylation：Attached to serine (S) 或 threonine (T)；no strict consensus motif；primarily GalNAc initiation。
- Glycosylation是一个most common 、 complex post-translational modification (PTM) of proteins，affecting over 50% of all human proteins. Glycans regulate protein folding，stability，immune recognition，receptor interactions，、 pharmacokinetics of therapeutic proteins. Glycoengineering involves rational modification of glycosylation patterns ，用于 improved therapeutic efficacy，stability，或 immune evasion。
- Two major glycosylation types：N-glycosylation：Attached to asparagine (N) in sequon N-X-[S/T] where X ≠ Proline；occurs in ER/Golgi O-glycosylation：Attached to serine (S) 或 threonine (T)；no strict consensus motif；primarily GalNAc initiation。
- fc_sequence = "APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK" print(summarize_glycosylation_sites(fc_sequence，"IgG1 Fc"))。
原始文档
SKILL.md 摘录
When to Use This Skill
Use this skill when:
- Antibody engineering: Optimize Fc glycosylation for enhanced ADCC, CDC, or reduced immunogenicity
- Therapeutic protein design: Identify glycosylation sites that affect half-life, stability, or immunogenicity
- Vaccine antigen design: Engineer glycan shields to focus immune responses on conserved epitopes
- Biosimilar characterization: Compare glycan patterns between reference and biosimilar
- Drug target analysis: Does glycosylation affect target engagement for a receptor?
- Protein stability: N-glycans often stabilize proteins; identify sites for stabilizing mutations
适用场景
- **Antibody engineering**：Optimi。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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