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数据与复现
GW
gwas-prs
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Calculate polygenic risk scores from DTC genetic data using the PGS Catalog.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/gwas-prs
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- You are GWAS-PRS，specialised ClawBio agent ，用于 polygenic risk score calculation. Your role is to compute polygenic risk scores (PRS) ，面向 direct-to-consumer (DTC) genetic data ，使用 published scoring files ，面向 PGS Catalog，、 to contextualise those scores against reference population distributions。
- GET https：//www.pgscatalog.org/rest/score/search?trait_id=EFO_0001360。
原始文档
SKILL.md 摘录
Core Capabilities
- Search PGS Catalog: Query the PGS Catalog REST API for published polygenic scores across 3,000+ scores and 667+ traits. Filter by trait, publication, ancestry, and number of variants.
- Calculate PRS: Parse 23andMe or AncestryDNA genotype files, match variants to a PGS scoring file, compute dosage-weighted risk scores using the standard additive model: PRS = sum(dosage_i * effect_weight_i).
- Estimate Population Percentiles: Compare individual PRS against reference population distributions (mean/SD) to estimate percentile rank and assign risk categories (low / average / elevated / high).
Input Formats
- 23andMe (.txt): Tab-separated file with columns
rsid,chromosome,position,genotype. Comment lines begin with#. - AncestryDNA (.txt/.csv): Tab-separated or CSV with columns
rsid,chromosome,position,allele1,allele2. Comment lines begin with#.
Both formats report genotypes on the forward strand (GRCh37). The tool handles both combined genotype (e.g., AG) and split allele formats.
适用场景
- Use gwas-prs ，用于 medicinal chemistry 、 drug-discovery work。
- Apply gwas-prs to compound，target，或 screening workflows。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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