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数据与复现
HR
hrd-analysis-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Homologous recombination deficiency (HRD) analysis for PARP inhibitor response prediction.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/hrd-analysis-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- HRD Analysis Agent provides comprehensive analysis of homologous recombination deficiency ，用于 predicting response to PARP inhibitors 、 platinum chemotherapy. It integrates genomic scarring signatures (LOH，TAI，LST)，BRCA1/2 status，、 HRD gene pathway analysis。
- When determining HRD status ，用于 PARP inhibitor eligibility。
- To calculate genomic instability scores (GIS) ，面向 tumor sequencing。
- 用于 analyzing BRCA1/2 、 HRD gene mutations。
- When predicting response to PARP inhibitors 或 platinum chemotherapy。
原始文档
SKILL.md 摘录
Core Capabilities
-
Genomic Scar Scoring: Calculate LOH, TAI, and LST scores from copy number data.
-
BRCA Pathway Analysis: Assess mutations in BRCA1, BRCA2, and 13 other HRD genes.
-
HRD Classification: Determine HRD-positive vs. HRD-negative status.
-
PARP Inhibitor Prediction: Predict response to olaparib, niraparib, rucaparib, talazoparib.
-
Platinum Sensitivity: Predict platinum chemotherapy sensitivity.
-
Reversion Detection: Identify BRCA reversion mutations restoring HR function.
HRD Scoring Components
| Score | Definition | Biological Basis |
|---|---|---|
| LOH | Loss of heterozygosity regions >15 Mb | Genomic scarring |
| TAI | Telomeric allelic imbalance | End-to-end fusions |
| LST | Large-scale state transitions | Break-induced repair |
| GIS | Combined LOH + TAI + LST | Overall HRD score |
HRD-Positive Threshold: GIS ≥ 42 (Myriad myChoice) or equivalent
HRD Gene Panel
| Gene | Function | HRD Contribution |
|---|---|---|
| BRCA1 | HR core component | Major |
| BRCA2 | RAD51 loading | Major |
| PALB2 | BRCA2 partner | Moderate-Major |
| RAD51C/D | HR mediators | Moderate |
| ATM | DNA damage sensing | Moderate |
| CHEK2 | Cell cycle checkpoint | Moderate |
| BARD1 | BRCA1 partner | Moderate |
| BRIP1 | Fanconi pathway | Moderate |
| CDK12 | Transcription | Variable |
| RAD51B | HR mediator | Low-Moderate |
适用场景
- When determining HRD status ，用于 PARP inhibitor eligibility。
- To calculate genomic instability scores (GIS) ，面向 tumor sequencing。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- Variant_Interpretation - For BRCA classification
- Liquid_Biopsy_Analytics_Agent - For ctDNA HRD monitoring
- Pan_Cancer_MultiOmics_Agent - For multi-omic context
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