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数据与复现
MP
mpn-research-assistant
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Research assistant for myeloproliferative neoplasms: literature, mutation analysis, treatment.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/mpn-research-assistant
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- mechanism = """ PPM1D inhibition → ↑p53 phosphorylation → ↑p53 stabilization → ↑DNA damage response → ↑apoptosis in mutant clones。
- ecm_markers = ['COL1A1'，'COL3A1'，'FN1'，'LAMA1'，'LAMB1']。
原始文档
SKILL.md 摘录
WHO 2022 Classification
- Polycythemia Vera (PV): JAK2V617F (95%), JAK2 exon 12 (3%)
- Essential Thrombocythemia (ET): JAK2V617F (55%), CALR (25%), MPL (5%)
- Primary Myelofibrosis (PMF): JAK2V617F (55%), CALR (25%), MPL (8%)
- Pre-PMF: Early fibrotic stage, better prognosis
- Overt PMF: Grade 2-3 fibrosis, splenomegaly
Driver Mutations
| Mutation | Gene Location | Mechanism | VAF Significance |
|---|---|---|---|
| JAK2V617F | 9p24.1 | Constitutive JAK-STAT activation | >50% → poor prognosis |
| CALR (type 1) | 19p13.2 | 52bp deletion, MPL activation | Better prognosis |
| CALR (type 2) | 19p13.2 | 5bp insertion, MPL activation | Intermediate |
| MPL W515L/K | 1p34.2 | TPO-independent signaling | Thrombocytosis |
High Molecular Risk (HMR) Mutations
- ASXL1, EZH2, SRSF2, IDH1/2, U2AF1
- ≥2 HMR mutations = very high risk
适用场景
- Use mpn-research-assistant ，用于 clinical，translational，或 medical research tasks。
- Apply mpn-research-assistant when healthcare-specific guidance is required。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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