AA
AAV vector design: capsid selection, promoter optimization, payload capacity.
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数据与复现
MU
multi-ancestry-prs-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Multi-ancestry polygenic risk score computation with ancestry-specific weighting.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/multi-ancestry-prs-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Multi-Ancestry PRS Agent provides AI-optimized polygenic risk score calculation designed to work across diverse ancestral populations. It addresses critical limitation of European-biased GWAS by integrating trans-ancestry methods，improving risk prediction ，用于 underrepresented populations 、 enabling equitable precision medicine。
- When calculating PRS ，用于 non-European ancestry individuals。
- 用于 developing trans-ancestry risk prediction models。
- To reduce PRS bias across ancestral populations。
- When integrating multi-ancestry GWAS summary statistics。
原始文档
SKILL.md 摘录
Core Capabilities
-
Multi-Ancestry PRS: Calculate ancestry-aware polygenic scores.
-
Trans-Ancestry Optimization: Optimize weights across populations.
-
Local Ancestry Integration: Account for admixed genomes.
-
Ensemble Methods: Combine multiple PRS approaches.
-
Ancestry Calibration: Population-specific score calibration.
-
Equity Assessment: Evaluate prediction fairness across groups.
Supported Ancestries
| Ancestry | Training Data Availability | PRS Performance |
|---|---|---|
| European (EUR) | Excellent | High |
| East Asian (EAS) | Good | Good |
| South Asian (SAS) | Moderate | Moderate |
| African (AFR) | Limited | Lower |
| Hispanic/Latino (AMR) | Limited | Variable |
| Middle Eastern (MID) | Very Limited | Lower |
Multi-Ancestry Methods
| Method | Approach | Best For |
|---|---|---|
| PRS-CSx | Cross-population shrinkage | Multi-ancestry |
| PRS-Multi | Multi-population training | Large cohorts |
| Ensemble | Combined methods | Best overall |
| Local Ancestry | Ancestry-specific weights | Admixed populations |
| GPSMult | Integrated multi-trait | Correlated traits |
适用场景
- When calculating PRS ，用于 non-European ancestry individuals。
- 用于 developing trans-ancestry risk prediction models。
- To reduce PRS bias across ancestral populations。
- When integrating multi-ancestry GWAS summary statistics。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- PRS_Net_Deep_Learning_Agent - Deep learning PRS
- Pharmacogenomics_Agent - Drug-gene interactions
- PopEVE_Variant_Predictor_Agent - Variant interpretation
- DiagAI_Agent - Clinical integration
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