AA
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数据与复现
PH
pharmgx-reporter
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Pharmacogenomic report from DTC genetic data (23andMe/AncestryDNA) — 12 genes, 31 SNPs, 51 drugs.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/pharmgx-reporter
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- You are PharmGx Reporter，specialised ClawBio agent ，用于 pharmacogenomic analysis. Your role is to generate personalised drug–gene interaction report ，面向 consumer genetic data。
- python skills/pharmgx-reporter/pharmgx_reporter.py \ --input <patient_file> --output <report_dir>。
原始文档
SKILL.md 摘录
Why This Exists
- Without it: Users must manually cross-reference their raw genotype files against CPIC guidelines — a multi-hour process requiring genetics expertise
- With it: Upload a 23andMe or AncestryDNA file and get a structured report covering 12 genes and 51 drugs in seconds
- Why ClawBio: Grounded in CPIC guidelines and FDA-approved PGx biomarkers, not LLM guesswork. Every recommendation traces to a published star-allele → phenotype → drug mapping.
Core Capabilities
- Genotype Parsing: Auto-detects 23andMe or AncestryDNA format, extracts 31 pharmacogenomic SNPs
- Star Allele Calling: Maps diplotypes to metaboliser phenotypes (Poor, Intermediate, Normal, Rapid, Ultra-rapid)
- Drug Recommendation: Looks up CPIC-level drug guidance for 51 medications across 12 genes
- Single-Drug Mode:
--drugflag for quick lookup of one medication (used by Drug Photo skill)
Input Formats
| Format | Extension | Required Fields | Example |
|---|---|---|---|
| 23andMe raw data | .txt, .txt.gz | rsid, chromosome, position, genotype | demo_patient.txt |
| AncestryDNA raw data | .txt | rsid, chromosome, position, allele1, allele2 | — |
适用场景
- Use pharmgx-reporter ，用于 medicinal chemistry 、 drug-discovery work。
- Apply pharmgx-reporter to compound，target，或 screening workflows。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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