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primekg
维护者 K-Dense Inc. (PrimeKG original from Harvard MIMS) · 最近更新 2026年4月1日
PrimeKG is a precision medicine knowledge graph that integrates over 20 primary databases and high-quality scientific literature into a single resource. It contains over 100,000 nodes and 4 million edges across 29 relationship types, including drug-target, disease-gene, and phenotype-disease associations. **Key capabilities:** - Search for nodes (genes, proteins, drugs, diseases, phenotypes) - Retrieve direct neighb….
原始来源
K-Dense-AI/claude-scientific-skills
https://github.com/K-Dense-AI/claude-scientific-skills/tree/main/scientific-skills/primekg
- 维护者
- K-Dense Inc. (PrimeKG original from Harvard MIMS)
- 许可
- Unknown
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- 检索 ，用于 nodes (genes，proteins，drugs，diseases，phenotypes)。
- 获取 direct neighbors (associated entities 、 clinical evidence)。
- 分析 local disease context (related genes，drugs，phenotypes)。
- Identify drug-disease paths (potential repurposing opportunities)。
- PrimeKG是一个precision medicine knowledge graph that integrates over 20 primary databases 、 high-quality scientific literature into single resource. It contains over 100，000 nodes 、 4 million edges across 29 relationship types，，涵盖 drug-target，disease-gene，、 phenotype-disease associations。
原始文档
SKILL.md 摘录
When to Use This Skill
This skill should be used when:
- Knowledge-based drug discovery: Identifying targets and mechanisms for diseases.
- Drug repurposing: Finding existing drugs that might have evidence for new indications.
- Phenotype analysis: Understanding how symptoms/phenotypes relate to diseases and genes.
- Multiscale biology: Bridging the gap between molecular targets (genes) and clinical outcomes (diseases).
- Network pharmacology: Investigating the broader network effects of drug-target interactions.
1. Search for Entities
Find identifiers for genes, drugs, or diseases.
from scripts.query_primekg import search_nodes
## 2. Get Neighbors (Direct Associations)
Retrieve all connected nodes and relationship types.
```python
from scripts.query_primekg import get_neighbors
适用场景
- **Knowledge-based drug discovery：** Identifying targets 、 mechanisms ，用于 diseases。
- **Drug repurposing：** Finding existing drugs that might have evidence ，用于 new indications。
- **Phenotype analysis：** Understanding how symptoms/phenotypes relate to diseases 、 genes。
- **Multiscale biology：** Bridging gap between molecular targets (genes) 、 clinical outcomes (diseases)。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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