AN
数据与复现
AnnData
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数据与复现
SP
spatial-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Spatial omics agent: integrate spatial data with imaging, protein, and genomic layers.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/spatial-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- SpatialAgent focuses on biological interpretation of spatial transcriptomics data，specifically aiming to propose mechanistic hypotheses about tissue organization 、 cellular interactions。
- Mechanistic Interpretation：When you have clusters 或 spatial domains 、 need to understand why they are organized that way。
- Cell-Cell Interaction：To predict 、 interpret ligand-receptor interactions in spatial context。
- Hypothesis Generation：To propose biological mechanisms driving observed spatial heterogeneity。
- Mechanistic Interpretation：When you have clusters 或 spatial domains 、 need to understand why they are organized that way. Cell-Cell Interaction：To predict 、 interpret ligand-receptor interactions in spatial context. * Hypothesis Generation：To propose biological mechanisms driving observed spatial heterogeneity。
原始文档
SKILL.md 摘录
Core Capabilities
- Tissue Organization Analysis: Decodes the structural logic of tissues (e.g., layers, niches).
- Cellular Interaction Prediction: Identifies potential signaling pathways active at domain boundaries.
- Hypothesis Proposal: Generates testable biological hypotheses based on spatial data.
Workflow
- Input Analysis: Accepts processed ST data (e.g., cluster annotations, DEG lists per spatial domain).
- Knowledge Retrieval: Queries biological knowledge bases regarding the observed cell types and genes.
- Synthesis: Constructs a narrative explaining the spatial arrangement (e.g., "The proximity of fibroblasts and tumor cells suggests a desmoplastic reaction mediated by TGF-beta signaling...").
Example Usage
User: "Why are the macrophages located at the boundary of the tumor core in this sample?"
Agent Action:
- Analyzes the gene expression of macrophages and adjacent tumor cells.
- Checks for ligand-receptor pairs (e.g., CSF1-CSF1R).
- Proposes: "Macrophages are likely recruited by CSF1 secreted by the tumor cells, forming an immunosuppressive barrier..."
适用场景
- **Mechanistic Interpretation**：When you have clusters 或 spatial domains 、 need to understand *why* they are organi。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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