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tcr-repertoire-analysis-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
TCR repertoire analysis: V(D)J usage, clonotype dynamics, antigen specificity.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tcr-repertoire-analysis-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- TCR Repertoire Analysis Agent provides comprehensive T-cell receptor repertoire analysis ，用于 cancer immunology applications. It leverages 深度学习 、 multi-layer 机器学习 approaches to analyze TCR diversity，predict immunotherapy response，identify tumor-reactive TCRs，、 support therapeutic TCR selection ，用于 cancer immunotherapy。
- When analyzing TCR repertoire ，用于 cancer diagnosis 、 staging。
- 用于 predicting immunotherapy (anti-PD-1/PD-L1) response ，面向 TCR profiles。
- To identify tumor-reactive TCRs ，用于 adoptive cell therapy。
- When monitoring treatment response through TCR clonality changes。
原始文档
SKILL.md 摘录
Core Capabilities
-
Repertoire Diversity Analysis: Quantify TCR diversity, clonality, and convergence.
-
Cancer Diagnosis: Distinguish cancer types from TCR signatures.
-
Immunotherapy Response Prediction: Predict checkpoint inhibitor response.
-
Tumor-Reactive TCR Identification: Find neoantigen-specific TCRs.
-
TCR-pMHC Binding Prediction: Predict TCR epitope specificity.
-
Clonal Dynamics Tracking: Monitor TCR clones during treatment.
TCR Repertoire Metrics
| Metric | Definition | Clinical Significance |
|---|---|---|
| Clonality | Gini coefficient of clone sizes | Immune focusing |
| Shannon Entropy | Diversity measure | Immune breadth |
| Richness | Unique clonotypes | Repertoire depth |
| Top Clone % | Largest clone fraction | Dominant response |
| Convergent TCRs | Shared across patients | Public epitope response |
| Tumor-Infiltrating % | TIL-derived TCRs | Tumor reactivity |
Workflow
-
Input: TCR-seq data (bulk or single-cell), clinical metadata.
-
Preprocessing: CDR3 extraction, error correction, clustering.
-
Repertoire Analysis: Calculate diversity, clonality, convergence.
-
ML Classification: Cancer type, stage, response prediction.
-
TCR Prioritization: Rank tumor-reactive TCR candidates.
-
TCR-pMHC Prediction: Predict epitope specificity.
-
Output: Repertoire metrics, predictions, therapeutic candidates.
适用场景
- Use tcr-repertoire-analysis-agent ，用于 clinical，translational，或 medical research tasks。
- Apply tcr-repertoire-analysis-agent when healthcare-specific guidance is required。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- TCR_pMHC_Prediction_Agent - Detailed TCR-epitope prediction
- Neoantigen_Prediction_Agent - Neoantigen identification
- TME_Immune_Profiling_Agent - Broader immune context
- TCell_Exhaustion_Analysis_Agent - T cell phenotyping
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