bio-imaging-mass-cytometry-spatial-analysis：Spatial analysis of cell neighborhoods 、 interactions in IMC data。 Covers ne…
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数据与复现
TO
tooluniverse-cancer-variant-interpretation
维护者 FreedomIntelligence · 最近更新 2026年4月1日
tooluniverse-cancer-variant-interpretation：提供 comprehensive clinical interpretation of somatic mutations in cancer。 Given gene symbol + variant (e.g.，EGFR L858R，BRAF V600E) 、 optional cancer type，performs multi-database analysis covering clinical evidence (CIViC)，mutation prevalence (cBioPortal)，therapeutic associations (OpenTargets，ChEMBL，FDA)，resistance mechanisms，clinical trials，prognostic impact，、 pathway context。
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-cancer-variant-interpretation
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Comprehensive clinical interpretation of somatic mutations in cancer. Transforms gene + variant input into actionable precision oncology report covering clinical evidence，therapeutic options，resistance mechanisms，clinical trials，、 prognostic implications。
- KEY PRINCIPLES：1. Report-first approach - Create report file FIRST，then populate progressively 2. Evidence-graded - Every recommendation has evidence tier (T1-T4) 3. Actionable output - Prioritized treatment options，not data dumps 4. Clinical focus - Answer "what should we treat ，支持?" not "what databases exist?" 5. Resistance-aware - Always check ，用于 known resistance mechanisms 6. Cancer-type specific - Tailor all recommendations to patient's cancer type when provided 7. Source-referenced - Every statement must cite tool/database source 8. English-first queries - Always use English terms in tool calls (gene names，drug names，cancer types)，even if user writes in another language. Respond in user's language。
- Date：{date} Cancer Type：{cancer_type 或 "Not specified"}。
原始文档
SKILL.md 摘录
When to Use
Apply when user asks:
- "What treatments exist for EGFR L858R in lung cancer?"
- "Patient has BRAF V600E melanoma - what are the options?"
- "Is KRAS G12C targetable?"
- "Patient progressed on osimertinib - what's next?"
- "What clinical trials are available for PIK3CA E545K?"
- "Interpret this somatic mutation: TP53 R273H"
- "Molecular tumor board: EGFR exon 19 deletion, NSCLC"
Input Parsing
Required: Gene symbol + variant notation Optional: Cancer type (improves specificity)
Accepted Input Formats
| Format | Example | How to Parse |
|---|---|---|
| Gene + amino acid change | EGFR L858R | gene=EGFR, variant=L858R |
| Gene + HGVS protein | BRAF p.V600E | gene=BRAF, variant=V600E |
| Gene + exon notation | EGFR exon 19 deletion | gene=EGFR, variant=exon 19 deletion |
| Gene + fusion | EML4-ALK fusion | gene=ALK, variant=EML4-ALK |
| Gene + amplification | HER2 amplification | gene=ERBB2, variant=amplification |
| Full query with cancer | "EGFR L858R in lung adenocarcinoma" | gene=EGFR, variant=L858R, cancer=lung adenocarcinoma |
适用场景
- 适合在oncologists，molecular tumor boards，或 researchers ask about treatment options ，用于 specific cancer mutations，resistance mechanisms，或 clinical trial matching时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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