AR
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数据与复现
TO
tooluniverse-polygenic-risk-score
维护者 FreedomIntelligence · 最近更新 2026年4月1日
tooluniverse-polygenic-risk-score：**Use Cases：** - "Calculate my genetic risk ，用于 type 2 diabetes" - "Build polygenic risk score ，用于 coronary artery disease" - "What's my genetic predisposition to Al。
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-polygenic-risk-score
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- 构建 、 interpret polygenic risk scores ，用于 complex diseases ，使用 genome-wide association study (GWAS) data。
- Calculate my genetic risk ，用于 type 2 diabetes。
- 构建 polygenic risk score ，用于 coronary artery disease。
- What's my genetic predisposition to Alzheimer's disease。
- Interpret my PRS percentile ，用于 breast cancer risk。
原始文档
SKILL.md 摘录
PRS Calculation Formula
A polygenic risk score is calculated as a weighted sum across genetic variants:
Where:
- dosage_i: Number of effect alleles at SNP i (0, 1, or 2)
- effect_size_i: Beta coefficient or log(odds ratio) from GWAS
Standardization
Raw PRS is standardized to z-scores for interpretation:
This allows comparison to population distribution and percentile calculation.
Significance Thresholds
- Genome-wide significance: p < 5×10⁻⁸ (default threshold)
- This corrects for ~1 million independent tests across the genome
- Relaxed thresholds (e.g., p < 1×10⁻⁵) can include more SNPs but may add noise
适用场景
- 适合在asked to calculate polygenic risk scores，interpret genetic risk ，用于 complex diseases，build custom PRS ，面向 GWAS data，或 answer questions like "What is my genetic predisposition to breast cancer?"时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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