tooluniverse-precision-medicine-stratification

When to Use

Apply when user asks:

• "Stratify this breast cancer patient: ER+/HER2-, BRCA1 mutation, stage II"
• "What is the risk profile for this diabetes patient with HbA1c 8.5 and CYP2C19 poor metabolizer?"
• "NSCLC patient with EGFR L858R, stage IV, TMB 25 - treatment strategy?"
• "Predict prognosis and recommend treatment for this cardiovascular patient"
• "Patient has Marfan syndrome with FBN1 mutation - risk stratification"
• "Alzheimer's risk assessment: APOE e4/e4, family history positive"
• "Personalized treatment plan for type 2 diabetes with genetic risk factors"
• "Which therapy is best for this patient's molecular profile?"

NOT for (use other skills instead):

• Single variant interpretation -> Use tooluniverse-variant-interpretation or tooluniverse-cancer-variant-interpretation
• Immunotherapy-specific prediction -> Use tooluniverse-immunotherapy-response-prediction
• Drug safety profiling only -> Use tooluniverse-adverse-event-detection
• Target validation -> Use tooluniverse-drug-target-validation
• Clinical trial search only -> Use tooluniverse-clinical-trial-matching
• Drug-drug interaction analysis only -> Use tooluniverse-drug-drug-interaction
• PRS calculation only -> Use tooluniverse-polygenic-risk-score

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Required Input

• Disease/condition: Free-text disease name (e.g., "breast cancer", "type 2 diabetes", "Marfan syndrome")
• At least one of: Germline variants, somatic mutations, gene list, or clinical biomarkers

Strongly Recommended

• Genomic data: Specific variants (e.g., "BRCA1 c.68_69delAG", "EGFR L858R"), gene names, or expression changes
• Clinical parameters: Age, sex, disease stage, biomarkers (HbA1c, PSA, LDL-C)