AD
数据与复现
Adaptyv
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数据与复现
PR
protein-interaction-network-analysis
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Analyze protein-protein interaction networks using STRING, BioGRID, and SASBDB databases. Maps protein identifiers, retrieves interaction networks with confidence scores, performs functional enrichment analysis (GO/KEGG/Reactome), and optionally includes structural data. No API key required for core functionality (STRING). Use when analyzing protein networks, discovering interaction partners, identifying functional….
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-protein-interactions
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Comprehensive protein interaction network analysis ，使用 ToolUniverse tools. Analyzes protein networks through 4-phase workflow：identifier mapping，network retrieval，enrichment analysis，、 optional structural data。
- result = analyze_protein_network( tu=tu，proteins=["TP53"，"MDM2"，"ATM"，"CHEK2"]，species=9606，# Human confidence_score=0.7 # High confidence )。
原始文档
SKILL.md 摘录
Features
✅ Identifier Mapping - Convert protein names to database IDs (STRING, UniProt, Ensembl) ✅ Network Retrieval - Get interaction networks with confidence scores (0-1.0) ✅ Functional Enrichment - GO terms, KEGG pathways, Reactome pathways ✅ PPI Enrichment - Test if proteins form functional modules ✅ Structural Data - Optional SAXS/SANS solution structures (SASBDB) ✅ Fallback Strategy - STRING primary (no API key) → BioGRID secondary (if key available)
Databases Used
| Database | Coverage | API Key | Purpose |
|---|---|---|---|
| STRING | 14M+ proteins, 5,000+ organisms | ❌ Not required | Primary interaction source |
| BioGRID | 2.3M+ interactions, 80+ organisms | ✅ Required | Fallback, curated data |
| SASBDB | 2,000+ SAXS/SANS entries | ❌ Not required | Solution structures |
Basic Usage
from tooluniverse import ToolUniverse
from python_implementation import analyze_protein_network
适用场景
- 适合在analyzing protein networks，discovering interaction partners，identifying functional modules，或 studying protein complexes时使用。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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