AL
数据与复现
alphafold
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数据与复现
TO
tooluniverse-systems-biology
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Comprehensive systems biology and pathway analysis using multiple pathway databases (Reactome, KEGG, WikiPathways, Pathway Commons, BioModels). Performs pathway enrichment, protein-pathway mapping, keyword searches, and systems-level analysis. Use when analyzing gene sets, exploring biological pathways, or investigating systems-level biology.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tooluniverse-systems-biology
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Comprehensive pathway 、 systems biology analysis integrating multiple curated databases to provide multi-dimensional view of biological systems，pathway enrichment，、 protein-pathway relationships。
- 分析 pathways ，用于 this gene list。
- What pathways is [protein] involved in。
- Find pathways related to [keyword/process]。
- 执行 pathway enrichment analysis。
原始文档
SKILL.md 摘录
Core Databases Integrated
| Database | Coverage | Strengths |
|---|---|---|
| Reactome | Human-curated reactions & pathways | Detailed mechanistic pathways with reactions |
| KEGG | Reference pathways across organisms | Metabolic maps, disease pathways, drug targets |
| WikiPathways | Community-curated pathways | Emerging processes, collaborative updates |
| Pathway Commons | Integrated meta-database | Aggregates multiple sources (Reactome, KEGG, etc.) |
| BioModels | Computational SBML models | Mathematical/dynamic systems biology models |
| Enrichr | Statistical enrichment | Pathway over-representation analysis |
Phase 1: Pathway Enrichment Analysis
When: Gene list provided (from experiments, screens, differentially expressed genes)
Objective: Identify biological pathways statistically over-represented in gene list
Tools Used
enrichr_gene_enrichment_analysis:
- Input:
gene_list: Array of gene symbols (e.g., ["TP53", "BRCA1", "EGFR"])library: Pathway database (e.g., "KEGG_2021_Human", "Reactome_2022")
- Output: Array of enriched pathways with p-values, adjusted p-values, genes
- Use: Statistical over-representation analysis
适用场景
- Use tooluniverse-systems-biology in 科研工作流 aligned ，支持 this subject area。
- Follow upstream documentation ，用于 full working procedure。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
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