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数据与复现
TU
tumor-heterogeneity-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Analyze intratumoral heterogeneity from bulk and single-cell sequencing data.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tumor-heterogeneity-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Tumor Heterogeneity Agent provides comprehensive analysis of intratumor heterogeneity (ITH) ，用于 understanding clonal architecture，tracking subclonal evolution，、 predicting therapy resistance. It integrates multi-region sequencing，single-cell data，、 longitudinal samples to reconstruct tumor phylogenies 、 identify actionable subclones。
- When analyzing multi-region tumor sequencing ，用于 clonal architecture。
- 用于 tracking clonal evolution under treatment pressure。
- To predict resistance emergence ，面向 subclonal populations。
- When assessing tumor heterogeneity impact on treatment response。
原始文档
SKILL.md 摘录
Core Capabilities
-
Clonal Deconvolution: Infer clonal populations and their frequencies.
-
Phylogeny Reconstruction: Build tumor evolutionary trees from variants.
-
Subclonal Tracking: Monitor subclone dynamics over time.
-
Resistance Prediction: Identify pre-existing resistant subclones.
-
Multi-Region Integration: Combine spatial heterogeneity data.
-
Single-Cell ITH: Integrate scDNA-seq for ground-truth clones.
Heterogeneity Metrics
| Metric | Definition | Clinical Relevance |
|---|---|---|
| MATH Score | Mutant-allele tumor heterogeneity | ITH quantification |
| Shannon Index | Clonal diversity | Evolutionary potential |
| Clone Count | Number of distinct clones | Complexity |
| Truncal Fraction | % truncal mutations | Targetability |
| ITH Score | Composite heterogeneity | Prognosis |
Workflow
-
Input: Multi-region/longitudinal WES/WGS, copy number, tumor purity.
-
Preprocessing: Variant calling, CNV calling, purity estimation.
-
CCF Estimation: Calculate cancer cell fraction for each mutation.
-
Clustering: Group mutations into clonal populations.
-
Phylogeny: Reconstruct evolutionary tree.
-
Temporal Analysis: Track clone dynamics over time.
-
Output: Clone structures, phylogenies, heterogeneity metrics.
适用场景
- Use tumor-heterogeneity-agent ，用于 single-cell 或 spatial omics analysis。
- Apply tumor-heterogeneity-agent to 聚类，integration，或 trajectory workflows。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- ctDNA_Dynamics_MRD_Agent - Liquid biopsy tracking
- Single_Cell_CNV_Agent - scDNA-seq analysis
- HRD_Analysis_Agent - Genomic instability
- Pan_Cancer_MultiOmics_Agent - Multi-omic integration
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