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数据与复现
TU
tumor-mutational-burden-agent
维护者 FreedomIntelligence · 最近更新 2026年4月1日
Compute TMB and assess its predictive value for immunotherapy response.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/tumor-mutational-burden-agent
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Tumor Mutational Burden Agent provides comprehensive TMB analysis ，用于 immunotherapy response prediction. It harmonizes TMB calculation across different assays，integrates ，支持 other biomarkers (PD-L1，MSI)，、 provides evidence-based therapy recommendations。
- When calculating TMB ，面向 panel sequencing，WES，或 WGS data。
- To harmonize TMB values across different assay 平台s。
- 用于 predicting immunotherapy response ，使用 TMB 、 integrated biomarkers。
- When determining TMB-High status ，用于 pembrolizumab eligibility。
原始文档
SKILL.md 摘录
Core Capabilities
-
TMB Calculation: Compute TMB from different sequencing platforms with appropriate normalization.
-
Platform Harmonization: Standardize TMB across FoundationOne, MSK-IMPACT, WES, and other assays.
-
TMB-High Classification: Apply FDA-approved and tumor-specific thresholds.
-
Biomarker Integration: Combine TMB with PD-L1, MSI, and gene signatures.
-
Response Prediction: ML models predicting ICI response from TMB-inclusive features.
-
Tumor-Specific Context: Interpret TMB relative to cancer type distributions.
TMB Calculation Methods
| Platform | Coverage | TMB Formula | Normalization |
|---|---|---|---|
| WES | 30-50 Mb | Nonsynonymous/coding Mb | Per exome size |
| FoundationOne | 1.1 Mb | Syn + nonsyn/panel Mb | FDA validated |
| MSK-IMPACT | 1.0-1.2 Mb | Nonsyn + splice/panel Mb | Panel-specific |
| TSO500 | 1.94 Mb | Coding mutations/Mb | Illumina validated |
| WGS | 3 Gb | Various metrics | Genome-wide |
TMB Thresholds
| Context | Threshold | Evidence |
|---|---|---|
| FDA (pan-tumor) | ≥10 mut/Mb | KEYNOTE-158 |
| Melanoma | ≥10 mut/Mb | Practice standard |
| NSCLC | ≥10 mut/Mb | Multiple trials |
| SCLC | ≥10 mut/Mb | Variable benefit |
| Colorectal (MSS) | Limited utility | MSI more predictive |
| Urothelial | ≥10 mut/Mb | IMvigor trials |
适用场景
- When calculating TMB ，面向 panel sequencing，WES，或 WGS data。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- Variant_Annotation - For mutation calling
- Liquid_Biopsy_Analytics_Agent - For blood-based TMB
- Immune_Checkpoint_Combination_Agent - For ICI selection
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