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vcf-manipulation
维护者 FreedomIntelligence · 最近更新 2026年4月1日
vcf-manipulation.
原始来源
FreedomIntelligence/OpenClaw-Medical-Skills
https://github.com/FreedomIntelligence/OpenClaw-Medical-Skills/tree/main/skills/vcf-manipulation
- 维护者
- FreedomIntelligence
- 许可
- MIT
- 最近更新
- 2026年4月1日
技能摘要
来自 SKILL.md 的关键信息
核心说明
- Merge，concat，sort，、 compare VCF files ，使用 bcftools。
- bcftools merge -l files.txt -Oz -o merged.vcf.gz。
原始文档
SKILL.md 摘录
Operations Overview
| Operation | Command | Use Case |
|---|---|---|
| Merge | bcftools merge | Combine samples from multiple VCFs |
| Concat | bcftools concat | Combine regions from multiple VCFs |
| Sort | bcftools sort | Sort unsorted VCF |
| Intersect | bcftools isec | Compare/intersect call sets |
| Subset | bcftools view | Extract samples or regions |
bcftools merge
Combine multiple VCF files with different samples at the same positions.
Output missing genotypes as ./. (default)
bcftools merge sample1.vcf.gz sample2.vcf.gz -Oz -o merged.vcf.gz
适用场景
- Use vcf-manipulation ，用于 genomics 、 bioinformatics workflows。
- Apply vcf-manipulation to sequencing，variant，或 omics analysis tasks。
不适用场景
- Do not rely on this catalog entry alone ，用于 installation 或 maintenance details。
上游相关技能
- vcf-basics - View and query VCF files
- filtering-best-practices - Filter variants before manipulation
- variant-normalization - Normalize before comparing
- vcf-statistics - Compare statistics after manipulation
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